(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

Base Information

Chemical Name:(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol
CAS No.:960357-00-0
Molecular Formula:C₂₇H₃₄ClIN₆O₆
Molecular Weight:700.961
Hs Code.:

Synonyms:(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

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Chemical Property of (1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

Chemical Property:

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Technology Process of (1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

There total 6 articles about (1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 884653-97-8
(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-(2,6-dichloro-purin-9-yl)-cyclopentane-1,2-diol

: 696-40-2
3-iodobenzylamine

: 960357-00-0
(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 96h;

Reference yield:

: 884653-95-6
carbonic acid (1S,4R)-4-(2,6-dichloro-purin-9-yl)-cyclopent-2-enyl ester ethyl ester

: 960357-00-0
(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

2: ruthenium trichloride; sodium periodate; water / ethyl acetate; acetonitrile / 0.17 h / 0 °C

3: triethylamine / dichloromethane / 96 h / 20 °C

With ruthenium trichloride; sodium periodate; water; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 60176-77-4
(1S,4R)-4-hydroxy-2-cyclopentenyl acetate

: 960357-00-0
(1S,2R,3S,5R)-(di-tert-butoxycarbonylamino)-5-[2-chloro-6-(3-iodobenzylamino)-purin-9-yl]-cyclopentane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; PS-triphenylphosphine / tetrahydrofuran / 0.08 h

1.2: 1 h / 50 °C

2.1: pyridine / tetrahydrofuran / 1 h / 20 - 40 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / tetrahydrofuran / 3 h / 20 °C

4.1: ruthenium trichloride; sodium periodate; water / ethyl acetate; acetonitrile / 0.17 h / 0 °C

5.1: triethylamine / dichloromethane / 96 h / 20 °C

With pyridine; ruthenium trichloride; sodium periodate; water; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; PS-triphenylphosphine; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate; acetonitrile;