sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

Base Information

Chemical Name:sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate
CAS No.:129099-66-7
Molecular Formula:C₂₂H₁₈F₂NO₄*Na
Molecular Weight:421.376
Hs Code.:

Synonyms:sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

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Technology Process of sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

There total 8 articles about sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 128995-69-7,130273-23-3
ethyl (+/-)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

: 129099-66-7
sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 3.5h;
DOI:10.1021/jm00173a013

Reference yield:

: 128995-63-1
2-cyano-3,3-bis(4-fluorophenyl)-2-propenal

: 129099-66-7
sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / benzene / 1 h / Heating

3: 72 percent / 1.) Et₃B, 2.) NaBH₄ / tetrahydrofuran; methanol / 1.) 0 deg C, 1 h, 2.) -78 deg C, 3.5 h

4: 100 percent / 1.0 M aq. NaOH / tetrahydrofuran / 3.5 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; triethyl borane; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/jm00173a013

Reference yield:

: 128995-65-3
2-cyano-3,3-bis(4-fluorophenyl)-2-propenol

: 129099-66-7
sodium (+/-)-(E)-erythro-8-cyano-9,9-bis(4-fluorophenyl)-3,5-dihydroxy-6,8-nonadienoate

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 16 h / Ambient temperature

2: 100 percent / benzene / 1 h / Heating

4: 72 percent / 1.) Et₃B, 2.) NaBH₄ / tetrahydrofuran; methanol / 1.) 0 deg C, 1 h, 2.) -78 deg C, 3.5 h

5: 100 percent / 1.0 M aq. NaOH / tetrahydrofuran / 3.5 h / 0 °C

With sodium hydroxide; sodium tetrahydroborate; triethyl borane; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1021/jm00173a013