diethyl 2-methoxy-2-malonate

Base Information

• Chemical Name: diethyl 2-methoxy-2-malonate
• CAS No.: 155568-57-3
• Molecular Formula: C₁₉H₂₄N₄O₆
• Molecular Weight: 404.423
• Mol file: 155568-57-3.mol

Synonyms:diethyl 2-methoxy-2-malonate

Chemical Property of diethyl 2-methoxy-2-malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-methoxy-2-malonate

There total 3 articles about diethyl 2-methoxy-2-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diethyl 2-methoxy-2-malonate (155568-48-2) → diethyl 2-methoxy-2-malonate (155568-57-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 0.833333h; under 2068.6 Torr;

DOI:10.1002/jhet.5570300544

Reference yield:

diethyl 2-malonate (155568-39-1) → diethyl 2-methoxy-2-malonate (155568-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) Br₂ / 1.) THF, -78 deg C

2: H₂ / Pd/C (10percent) / methanol

With hydrogen; bromine; sodium hydride; palladium on activated charcoal; In methanol;

DOI:10.1016/0040-4039(94)85016-X

Reference yield:

2-(1-Benzyl-5-nitro-1H-imidazole-4-carbonylimino)-malonic acid diethyl ester → diethyl 2-methoxy-2-malonate (155568-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N HCl

2: 90 percent / H₂ / 5percent Pd/C / methanol / 0.83 h / 2068.6 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1002/jhet.5570300544

upstream raw materials:

diethyl 2-methoxy-2-malonate

diethyl 2-malonate

Downstream raw materials:

5-amino-1-(phenylmethyl)-1H-imidazole-4-carboxamide

3-benzyl-4,5,7,8-tetrahydro-6-methoxy-6-methoxycarbonyl-6H-imidazo<4,5-e><1,4>diazepine-5,8-dione