2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

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Chemical Name:2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one
CAS No.:1044277-15-7
Molecular Formula:C₂₃H₂₃N₅O₅S
Molecular Weight:481.532
Hs Code.:

Synonyms:2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

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Chemical Property of 2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

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Technology Process of 2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

There total 5 articles about 2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1044277-32-8
C₁₈H₂₁N₃O₄

: 6451-50-9
2-amino-5-methoxybenzenesulphonamide

: 1044277-15-7
2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

Guidance literature:: C₁₈H₂₁N₃O₄; 2-amino-5-methoxybenzenesulphonamide; With pyridine; at 120 ℃; for 2h;

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 120 ℃; for 15h;

Reference yield:

: ethyl (E)-2-(2-benzylhydrazono)acetate

: 1044277-15-7
2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / ethyl acetate / 0.5 h / 60 °C

2.1: 1,4-dioxane / 2 h / 85 °C

2.2: 16 h / 23 °C

3.1: sodium ethanolate / ethanol / 2 h / 65 °C

4.1: pyridine / 2 h / 120 °C

4.2: 15 h / 120 °C

With pyridine; N-chloro-succinimide; sodium ethanolate; In 1,4-dioxane; ethanol; ethyl acetate;

Reference yield:

: (Z)-ethyl 2-chloro-2-(2-benzylhydrazono)acetate

: 1044277-15-7
2-benzyl-5-hydroxy-4-(7-methoxy-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-6-pyrrolidin-1-yl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane / 2 h / 85 °C

1.2: 16 h / 23 °C

2.1: sodium ethanolate / ethanol / 2 h / 65 °C

3.1: pyridine / 2 h / 120 °C

3.2: 15 h / 120 °C

With pyridine; sodium ethanolate; In 1,4-dioxane; ethanol;