4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

Base Information

Chemical Name:4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid
CAS No.:1112182-62-3
Molecular Formula:C₁₆H₂₁N₅O₃
Molecular Weight:331.374
Hs Code.:

Synonyms:4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

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Chemical Property of 4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

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Technology Process of 4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

There total 6 articles about 4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25462-85-5
2-chloro-6-methylpyridine-4-carboxylic acid

: 1112182-62-3
4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 15 h / 20 °C

2: dichloromethane / 15 h / 20 °C

3: trichlorophosphate / toluene / 15 h / 110 °C

4: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux

5: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr

6: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

7: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; oxalyl dichloride; di-tert-butyl-diazodicarboxylate; water; palladium diacetate; triethylamine hydrochloride; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b01434

Reference yield:

: 26413-58-1
2-chloro-6-methyl-4-pyridinecarbonyl chloride

: 1112182-62-3
4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 15 h / 20 °C

2: trichlorophosphate / toluene / 15 h / 110 °C

3: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux

4: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr

5: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

6: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; di-tert-butyl-diazodicarboxylate; water; palladium diacetate; triethylamine hydrochloride; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.5b01434

Reference yield:

: 1112181-60-8
N-tert-butyl-2-chloro-6-methyl-pyridine-4-carboxamide

: 1112182-62-3
4-(2-(((trans)-4-(hydroxymethyl)cyclohexyl)methyl)-2H-tetrazol-5-yl)-6-methylpicolinic acid

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / toluene / 15 h / 110 °C

2: triethylamine hydrochloride; sodium azide / toluene / 4 h / Reflux

3: triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / 24 h / 100 °C / 6205.94 - 9826.07 Torr

4: di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

5: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; sodium azide; di-tert-butyl-diazodicarboxylate; water; palladium diacetate; triethylamine hydrochloride; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; toluene;
DOI:10.1021/acs.jmedchem.5b01434