Technology Process of (3α,5α,11β)-3,11-bis(benzyloxy)pregn-16-en-20-one
There total 27 articles about (3α,5α,11β)-3,11-bis(benzyloxy)pregn-16-en-20-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminum oxide;
In
benzene;
at 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1021/jo102054r
- Guidance literature:
-
(3α,5α,11β)-3,11-bis(benzyloxy)-20-oxopregn-16-en-21-yl acetate;
With
methylmagnesium bromide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2.5h;
Inert atmosphere;
Cooling with ice;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/jm401799j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C / Inert atmosphere; Reflux
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere; Reflux
3.1: pyridine hydrochloride / 2 h / 135 °C / Inert atmosphere
4.1: chromium(VI) oxide; sodium acetate; acetic anhydride; acetic acid / water / 0.67 h / 0 °C / Inert atmosphere
5.1: aluminum oxide / benzene / 2.5 h / 20 °C / Inert atmosphere
With
chromium(VI) oxide; aluminum oxide; lithium aluminium tetrahydride; sodium acetate; pyridine hydrochloride; acetic anhydride; sodium hydride; acetic acid;
In
tetrahydrofuran; water; mineral oil; benzene;
3.1: Marker's degradation;
DOI:10.1021/jo102054r
