C₃₃H₃₉FN₆O₅

Base Information

• Chemical Name: C₃₃H₃₉FN₆O₅
• CAS No.: 1449278-77-6
• Molecular Formula: C₃₃H₃₉FN₆O₅
• Molecular Weight: 618.708
• Mol file: 1449278-77-6.mol

Synonyms:C₃₃H₃₉FN₆O₅

Chemical Property of C₃₃H₃₉FN₆O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₉FN₆O₅

There total 12 articles about C₃₃H₃₉FN₆O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-[2-(4-bromoimidazol-1-yl)ethyl]morpholine (877399-20-7) + C30H37BFN3O6 (1449278-75-4) → C33H39FN6O5 (1449278-77-6)

Guidance literature:

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate; In 1,2-dimethoxyethane; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

C14H9FIN3 (1449278-73-2) → C33H39FN6O5 (1449278-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere; Sealed tube

3: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / 1,2-dimethoxyethane / 2 h / 100 °C / Inert atmosphere

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

ethyl 8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxylate (1449277-90-0) → C33H39FN6O5 (1449278-77-6)

Guidance literature:

Multi-step reaction with 5 steps

1: water; sodium hydroxide / methanol / 2 h / 50 °C / Inert atmosphere

2: N-iodo-succinimide; [bis(acetoxy)iodo]benzene / acetonitrile; water / 0.67 h / 60 °C / Inert atmosphere

3: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere; Sealed tube

5: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / 1,2-dimethoxyethane / 2 h / 100 °C / Inert atmosphere

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; [bis(acetoxy)iodo]benzene; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); water; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;

upstream raw materials:

C₁₄H₉FIN₃

4-[2-(4-bromoimidazol-1-yl)ethyl]morpholine

C₃₀H₃₇BFN₃O₆

ethyl 8-amino-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxylate

Downstream raw materials:

2-(3-fluorophenyl)-5-(1-(2-morpholinoethyl)-1H-imidazol-4-yl)-1,7-naphthyridin-8-amine

Refernces