4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline

Base Information

• Chemical Name: 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline
• CAS No.: 288384-74-7
• Molecular Formula: C₂₃H₂₆ClFN₄O₃
• Molecular Weight: 460.936

Synonyms:4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline

Chemical Property of 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline

There total 6 articles about 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester (288384-72-5) + 4-(4-chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline trifluoroacetate (288384-73-6) → 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline (288384-74-7)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 90 ℃; for 5h;

Reference yield:

concentrated aqueous ammonium hydroxide + trifluoroacetic acid salt of 4-(4-chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline + toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester (288384-72-5) → 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline (288384-74-7)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

concentrated aqueous ammonium hydroxide + toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester (288384-72-5) + trifluoroacetic acid salt of 4-(4-chloro-2-fluorophenoxy)-7-hydroxy6-methoxyquinazoline → 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline (288384-74-7)

Guidance literature:

With potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester

4-(4-chloro-2-fluorophenoxy)-7-hydroxy-6-methoxyquinazoline trifluoroacetate

1-methyl-piperazine

3-(4-methyl-1-piperazinyl)-1-propanol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 288384-74-7 4-(4-chloro-2-fluorophenoxy)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazoline

Send

Send

Metric Ton KG G Pound L ML

Send

Send