1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

Base Information

Chemical Name:1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B
CAS No.:83866-01-7
Molecular Formula:C₃₉H₄₄F₂N₄O₁₀
Molecular Weight:766.796
Hs Code.:

Synonyms:1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

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Chemical Property of 1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

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Technology Process of 1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

There total 2 articles about 1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 83866-00-6
1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3-de(methoxy)-3-oxo-sporaricin B

: 83866-01-7
1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1016/0008-6215(83)88117-8

Reference yield:

: 81090-88-2,81131-62-6,83916-87-4
1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3-de(O-methyl)sporaricin B

: 83866-01-7
1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Heating

2: 72 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 3 h / Ambient temperature

With diethylamino-sulfur trifluoride; pyridinium chlorochromate; In dichloromethane;
DOI:10.1016/0008-6215(83)88117-8

Reference yield:

: 83866-01-7
1,2',6'-tris(N-benzyloxycarbonyl)-4-N,5-O-carbonyl-3,3-difluoro-3-de(methoxy)sporaricin B

: 87069-53-2
3,3-difluoro-3-de(methoxy)sporaricin A hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 0.25 M barium hydroxide; 2.) triethylamine / 1.) 1,4-dioxane, water, 1.5 h, 80 deg C; 2.) oxolane, 2 d, 37 deg C

2: 57 percent / 0.2 M hydrogen chloride, hydrogen / 10 percent palladium-on-charcoal / methanol / 760 Torr

With hydrogenchloride; barium dihydroxide; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1016/0008-6215(83)88117-8