3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Base Information

• Chemical Name: 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid
• CAS No.: 1219111-68-8
• Molecular Formula: C₂₂H₂₁NO₅
• Molecular Weight: 379.412
• Mol file: 1219111-68-8.mol

Synonyms:3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Chemical Property of 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid

There total 6 articles about 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carbaldehyde (1219111-74-6) → 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid (1219111-68-8)

Guidance literature:

With sodium chlorite; aminosulfonic acid; In water; acetone; at 20 ℃;

DOI:10.1111/cbdd.12358

Reference yield:

3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-methylpyridin-4(1H)-one (1219111-72-4) → 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid (1219111-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide; acetic acid; acetic anhydride / 90 - 100 °C / Reflux

2: sodium chlorite; aminosulfonic acid / water; acetone / 20 °C

With selenium(IV) oxide; sodium chlorite; aminosulfonic acid; acetic anhydride; acetic acid; In water; acetone;

DOI:10.1111/cbdd.12358

Reference yield:

Maltol (118-71-8) → 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid (1219111-68-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / methanol / Reflux

2: sodium hydroxide / water; methanol / 2.5 h / Reflux

3: sodium hydride / tetrahydrofuran / 3 h / Reflux

4: selenium(IV) oxide; acetic acid; acetic anhydride / 90 - 100 °C / Reflux

5: sodium chlorite; aminosulfonic acid / water; acetone / 20 °C

With selenium(IV) oxide; sodium chlorite; aminosulfonic acid; acetic anhydride; sodium hydride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; acetone;

DOI:10.1111/cbdd.12358

upstream raw materials:

3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-4-oxo-1,4-dihydropyridine-2-carbaldehyde

3-benzyloxy-1-(2-hydroxyethyl)-2-methyl-4(1H)-pyridinone

3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-methylpyridin-4(1H)-one

Maltol