[(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester
CAS No.:781642-15-7
Molecular Formula:C₃₈H₅₇NO₆Si
Molecular Weight:651.959
Hs Code.:

Synonyms:[(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

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Chemical Property of [(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

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Technology Process of [(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

There total 7 articles about [(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 781642-14-6
[(6E,10E)-(4R,8S)-8-(tert-Butyl-diphenyl-silanyloxy)-4-methoxymethoxy-12-oxo-dodeca-6,10-dienyl]-carbamic acid tert-butyl ester

: 781642-15-7
[(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

Guidance literature:: In diethyl ether; at -78 ℃;
DOI:10.1021/ol048862i

Reference yield:

: 84766-90-5
4-[N-(tert-butyloxycarbonyl)]amino-1-butanal

: 781642-15-7
[(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / diethyl ether / -78 °C

2: 81 percent / Cl₂Ru(C₃H₅N₂(Mes)2)(C₁₀H₁₂O) / CH₂Cl₂ / 4 h / 25 °C

3: 91 percent / i-Pr₂NEt / CH₂Cl₂ / 25 °C

4: diethyl ether / -78 °C

5: 88 percent / imidzole / CH₂Cl₂ / 1 h / 25 °C

6: 53 percent / Cl₂Ru(C₃H₅N₂(Mes)2)(C₁₀H₁₂O) / CH₂Cl₂ / 24 h / 25 °C

7: 85 percent / diethyl ether / -78 °C

With 1H-imidazole; Cl₂Ru(C₃H₅N₂(Mes)2)(C₁₀H₁₂O); N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ol048862i

Reference yield:

: 781642-09-9
(R)-tert-butyl 4-hydroxyhept-6-enylcarbamate

: 781642-15-7
[(6E,10E)-(4R,8S,12S)-8-(tert-Butyl-diphenyl-silanyloxy)-12-hydroxy-4-methoxymethoxy-pentadeca-6,10,14-trienyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / Cl₂Ru(C₃H₅N₂(Mes)2)(C₁₀H₁₂O) / CH₂Cl₂ / 4 h / 25 °C

2: 91 percent / i-Pr₂NEt / CH₂Cl₂ / 25 °C

3: diethyl ether / -78 °C

4: 88 percent / imidzole / CH₂Cl₂ / 1 h / 25 °C

5: 53 percent / Cl₂Ru(C₃H₅N₂(Mes)2)(C₁₀H₁₂O) / CH₂Cl₂ / 24 h / 25 °C

6: 85 percent / diethyl ether / -78 °C

With 1H-imidazole; Cl₂Ru(C₃H₅N₂(Mes)2)(C₁₀H₁₂O); N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ol048862i