3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

Base Information

Chemical Name:3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde
CAS No.:215809-19-1
Molecular Formula:C₁₆H₁₄N₂OS₄
Molecular Weight:378.564
Hs Code.:

Synonyms:3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

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Chemical Property of 3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

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Technology Process of 3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

There total 4 articles about 3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 215809-11-3
1,2-bis(2-thioxo-2,3-dihydrothiazol-3-yl)benzene

: 215809-19-1
3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; 1.) -80 deg C, 0.5 h, 2.) -80 deg C to r.t.; r.t., 5 h;
DOI:10.1055/s-1998-2183

Reference yield:

: 879283-39-3,879283-40-6,215809-07-7
3-(2-aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione

: 215809-19-1
3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) reflux, 1 h, 2.) r.t., 10 h

2: 2.) H₂SO₄ / 1.) MeCN, overnight, 2.) 15 min

3: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -80 deg C, 0.5 h, 2.) -80 deg C to r.t.; r.t., 5 h

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;
DOI:10.1055/s-1998-2183

Reference yield:

: (2-Amino-phenyl)-dithiocarbamic acid; compound with triethyl-amine

: 215809-19-1
3-[2-(4,5-dimethyl-2-thioxo-2,3-dihydrothiazol-3-yl)phenyl]-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) H₂SO₄ / 1.) MeCN, r.t., 12 h, 2.) 15 min

2: 1.) reflux, 1 h, 2.) r.t., 10 h

3: 2.) H₂SO₄ / 1.) MeCN, overnight, 2.) 15 min

4: 68 percent / BuLi / tetrahydrofuran; hexane / 1.) -80 deg C, 0.5 h, 2.) -80 deg C to r.t.; r.t., 5 h

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;
DOI:10.1055/s-1998-2183