(Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile

Base Information

• Chemical Name: (Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile
• CAS No.: 1469863-93-1
• Molecular Formula: C₁₄H₁₄N₄
• Molecular Weight: 238.292
• Mol file: 1469863-93-1.mol

Synonyms:(Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile

Chemical Property of (Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile

Chemical Property:

Purity/Quality:

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Technology Process of (Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile

There total 1 articles about (Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2-(5-phenyl-1H-pyrazol-3-yl)acetonitrile (202129-57-5) → (Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile (1469863-93-1)

Guidance literature:

In tetrahydrofuran; at 80 - 90 ℃;

DOI:10.1016/j.tetlet.2014.01.095

Reference yield: 31.0%

(Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile (1469863-93-1) + benzamide (55-21-0,27208-38-4) → 2-pheny-7-phenylpyrazolo[1,5-c]pyrimidine

Guidance literature:

With trifluoroacetic acid; at 130 - 140 ℃; for 50h;

DOI:10.1016/j.tetlet.2014.01.095

Reference yield: 31.0%

2-aminopyridine (504-29-0) + (Z)-3-(dimethylamino)-2-(5-phenyl-1H-pyrazol-3-yl)acrylonitrile (1469863-93-1) → 3-(5-phenyl-1H-pyrazol-3-yl)-2H-pyrido[1,2-a]pyrimidin-2-one (1469863-94-2)

Guidance literature:

With trifluoroacetic acid; at 130 - 140 ℃; for 50h;

DOI:10.1016/j.tetlet.2014.01.095

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

2-(5-phenyl-1H-pyrazol-3-yl)acetonitrile

Downstream raw materials:

3-(5-phenyl-1H-pyrazol-3-yl)-2H-pyrido[1,2-a]pyrimidin-2-one