Technology Process of C62H88N13O14PCoCH2CH2CH(COCH3)(CH2C6H5)
There total 2 articles about C62H88N13O14PCoCH2CH2CH(COCH3)(CH2C6H5) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
zinc;
In
water;
into a soln. of B12s prepared by reducing cyanocobalamin with Zn dust (pretreated with 1-10% HCl) in 15% aq. NH4Cl was added alkyl chloride under N2 in the dark, mixt. was stirred for 0.5-3 h at room temp.; extd. with 1:1 phenol-CH2Cl2, alkylcobalamine was extd. with water, water was removed at <40°C at 1 mm Hg, residue was chromd. on a column of cellulose CM-52 (water), recrystd. from acetone-water; 1:1 diastereomer mixt.; spectral identification;
DOI:10.1021/om00153a025
- Guidance literature:
-
With
ammonium chloride; zinc;
In
water;
into a soln. of B12s prepared by reducing cyanocobalamin with Zn dust (pretreated with 1-10% HCl) in 15% aq. NH4Cl was added cyclopropane under N2 in the dark, mixt. was stirred for 0.5-3 h at room temp.; extd. with 1:1 phenol-CH2Cl2, alkylcobalamine was extd. with water, water was removed at <40°C at 1 mm Hg, residue was chromd. on a column of cellulose CM-52 (water), recrystd. from acetone-water; 1:2.0 diastereomer mixt.; spectral identification;
DOI:10.1021/om00153a025
