8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

Base Information

Chemical Name:8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester
CAS No.:119280-45-4
Molecular Formula:C₂₁H₂₇F₃O₆
Molecular Weight:432.437
Hs Code.:

Synonyms:8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

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Chemical Property of 8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

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Technology Process of 8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

There total 10 articles about 8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 119258-81-0,119325-00-7
8-Hydroxy-8-oxiranyl-octanoic acid methyl ester

: 119280-45-4
8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)86037-2

Reference yield: 73.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 119258-81-0
(S)-8-Hydroxy-8-(R)-oxiranyl-octanoic acid methyl ester

: 119280-45-4
(S)-8-(R)-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)86037-2

Reference yield:

: 931-88-4,931-87-3,25267-51-0
cis-Cyclooctene

: 119280-45-4
8-Oxiranyl-8-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) O₃, 2.) Ac₂O, NEt₃ / 1.) CH₂Cl₂, -78 deg C, 2.) benzene

2: 68 percent / tetrahydrofuran / -78 °C

3: 95 percent / MCPBA / CH₂Cl₂ / Heating

4: PDC, 3 Angstroem molecular sieves / acetic acid; CH₂Cl₂ / Ambient temperature

5: ZnBH₄ / diethyl ether / 0 °C

6: 73 percent / pyridine / CH₂Cl₂ / Ambient temperature

With pyridine; dipyridinium dichromate; zinc(II) tetrahydroborate; 3 A molecular sieve; acetic anhydride; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(00)86037-2