8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

Base Information

Chemical Name:8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide
CAS No.:1331783-66-4
Molecular Formula:C₂₄H₂₂Cl₃N₇O
Molecular Weight:530.844
Hs Code.:

Synonyms:8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

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Chemical Property of 8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

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Technology Process of 8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

There total 3 articles about 8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 337526-61-1
8-chloro-1-(2′,4′-dichlorophenyl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxylic acid

: 1331783-96-0
2-(1-methyl-1H-tetrazol-5-yl)propan-2-amine

: 1331783-66-4
8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 1331783-94-8
benzyl (2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)carbamate

: 1331783-66-4
8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C

With 20% palladium hydroxide on carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.06.017

Reference yield:

: 24127-36-4
2-chloro-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-one

: 5446-18-4
2,4-dichlorophenyl hydrazine hydrochloride

: 1331783-66-4
8-chloro-1-(2,4-dichlorophenyl)-N-(2-(1-methyl-1H-tetrazol-5-yl)propan-2-yl)-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / diethyl ether / 14 h / -78 - 20 °C

1.2: 16 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; In diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2011.06.017