(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Base Information

Chemical Name:(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole
CAS No.:154129-83-6
Molecular Formula:C₂₄H₂₈N₂O₃S
Molecular Weight:424.564
Hs Code.:

Synonyms:(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Suppliers and Price of (1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

There total 11 articles about (1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145654-99-5
(S)-2-(benzyl-tert-butoxycarbonyl-amino)-3-phenyl-propionic acid methyl ester

: 154129-83-6
(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: DIBALH / CH₂Cl₂; toluene / 2 h / -78 °C

2: 2.) Bu₄NF*3H₂O / 1.) CH₂Cl₂, -20 deg C, 48 h, 2.) THF, r.t. 1 h

With tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1021/jo00129a057

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 154129-83-6
(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Guidance literature:: Multi-step reaction with 8 steps

1: 2.5 g / 48 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 18 h / Ambient temperature

3: NaBH₄ / methanol / 0.5 h / 0 °C

4: NaBH₄ / dioxane / 18 h / Ambient temperature

5: 91 percent / BuLi / hexane; diethyl ether / 4 h / -65 °C

6: 95 percent / TFA / H₂O / 0.5 h / Ambient temperature

7: 92 percent / DIBAH / tetrahydrofuran; toluene / 1.) -78 deg C, 1 h; 2.) rt., 30 min

8: dioxane / 18 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; water; toluene;
DOI:10.1055/s-1993-26021

Reference yield:

: 66399-75-5,84028-90-0
(S)-2-benzylamino-3-phenyl-propionic acid methyl ester

: 154129-83-6
(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / dioxane / 18 h / Ambient temperature

2: 91 percent / BuLi / hexane; diethyl ether / 4 h / -65 °C

3: 95 percent / TFA / H₂O / 0.5 h / Ambient temperature

4: 92 percent / DIBAH / tetrahydrofuran; toluene / 1.) -78 deg C, 1 h; 2.) rt., 30 min

5: dioxane / 18 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; toluene;
DOI:10.1055/s-1993-26021