(S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Base Information

Chemical Name:(S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid
CAS No.:273221-87-7
Molecular Formula:C₂₄H₁₉F₂NO₅
Molecular Weight:439.415
Hs Code.:

Synonyms:(S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Suppliers and Price of (S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

There total 2 articles about (S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2713-34-0
3,5-difluorophenol

: 273221-87-7
(S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NH4OAc, tyrosine phenollylase, pyridoxal-5'-phosphate, β-mercaptoethanol, NH4OH / H2O / Ambient temperature

2: 10percent aq. Na₂CO₃ / dioxane / Ambient temperature

With ammonium hydroxide; tyrosine phenollylase; pyridoxal 5'-phosphate; ammonium acetate; sodium carbonate; 2-hydroxyethanethiol; In 1,4-dioxane; water;
DOI:10.1021/ja9808393

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 182756-57-6
2,6-Difluoro-l-tyrosine

: 273221-87-7
(S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; Ambient temperature;
DOI:10.1021/ja9808393

Reference yield:

: 273221-87-7
(S)-3-(2,6-Difluoro-4-hydroxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

: C₃₄H₄₇F₂N₈O₂₀P

Guidance literature:: Multi-step reaction with 2 steps

2: ATP, Csk, pyruvate kinase-lactate dehydrogenase, phosphenolpyruvate, DTT, MnCl₂, Tris-HCl pH 7.4 / H₂O / 48 h / 30 °C

With DL-dithiothreitol; phosphenolpyruvate; pyruvate kinase-lactate dehydrogenase; tris hydrochloride; ATP; manganese(ll) chloride; In water;
DOI:10.1021/ja9808393