methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate

Base Information

• Chemical Name: methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate
• CAS No.: 176794-75-5
• Molecular Formula: C₁₈H₁₆N₂O₆
• Molecular Weight: 356.335
• Mol file: 176794-75-5.mol

Synonyms:methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate

Chemical Property of methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate

There total 2 articles about methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-nitrobenzaldehdye (555-16-8) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate (176794-75-5)

Guidance literature:

DOI:10.1002/ejoc.200500937

Reference yield: 49.0%

4-nitrobenzyl chloride (619-73-8) + N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester (100945-15-1,88568-95-0) → methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate (176794-75-5)

Guidance literature:

With manganese(IV) oxide; 1-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1055/s-2002-19755

Reference yield:

methyl (2Z)-2-{[(benzyloxy)carbonyl]amino}-3-(4-nitrophenyl)prop-2-enoate (176794-75-5) → (R)-2-Benzyloxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester

Guidance literature:

With hydrogen; [Rh(COD)(S)-EtButiPhane][BF₄]; In methanol; at 35 ℃; for 17h; under 7500.6 Torr;

DOI:10.1002/ejoc.200500937

upstream raw materials:

4-nitrobenzyl chloride

N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

4-nitrobenzaldehdye