N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide

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Chemical Name:N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide
CAS No.:1033624-83-7
Molecular Formula:C₂₅H₂₄F₃N₃O₃S
Molecular Weight:503.545
Hs Code.:

Synonyms:N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide

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Technology Process of N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide

There total 1 articles about N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1033624-86-0
5-bromo-2-(4-trifluoromethyl-phenoxymethyl)-1H-benzoimidazole

: 150691-04-6
2-(tert-butylamino)sulfonylphenylboronic acid

: 1033624-83-7
N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide

Guidance literature:: 5-bromo-2-(4-trifluoromethyl-phenoxymethyl)-1H-benzoimidazole; 2-(tert-butylamino)sulfonylphenylboronic acid; With sodium carbonate; In 1,2-dimethoxyethane; water; for 1h;

dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1,2-dimethoxyethane; water; at 61 - 78 ℃; for 12.5h; Product distribution / selectivity;

Reference yield: 95.0%

: 1033624-83-7
N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide

: 1033622-90-0
2-[2-(4-trifluoromethyl-phenoxymethyl)-1H-benzoimidazol-5-yl]-benzenesulfonamide

Guidance literature:: N-tert-butyl-2-[2-(4-trifluoromethyl-phenoxymethyl)-1H benzoimidazol-5-yl]-benzenesulfonamide; With trifluoroacetic acid; at 75 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; Product distribution / selectivity;