(E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

Base Information

Chemical Name:(E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester
CAS No.:129360-98-1
Molecular Formula:C₂₉H₃₄F₂N₂O₄
Molecular Weight:512.597
Hs Code.:

Synonyms:(E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

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Chemical Property of (E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

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Technology Process of (E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

There total 10 articles about (E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97-94-9
triethyl borane

: ammonium chloride

: 152770-14-4
(E,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethyleth-1-yl ester

: 129360-98-1
(E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

Guidance literature:: With sodium borohydrid; In tetrahydrofuran; methanol;

Reference yield:

: 129360-64-1
4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole

: 129360-98-1
(E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 6 h / Heating

2: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 3 deg C, 20 min, 2.) THF, hexane, -40 deg C, 4 h

3: NaOMe / 2.5 h / Ambient temperature

4: 1.) LDA / 1.) cyclohexane, hexane, 3 deg C, 30 min, 2.) cyclohexane, hexane, THF, 3 deg C, 1 h

5: NaBH₄, AcOH / 15 - 20 °C

With sodium tetrahydroborate; sodium methylate; lithium dicyclohexylamide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jm00075a020

Reference yield:

: 129360-69-6
(E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol

: 129360-98-1
(E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / MnO₂ / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) lithium dicyclohexylamide / 1.) THF, hexane, 3 deg C, 20 min, 2.) THF, hexane, -40 deg C, 4 h

3: NaOMe / 2.5 h / Ambient temperature

4: 1.) LDA / 1.) cyclohexane, hexane, 3 deg C, 30 min, 2.) cyclohexane, hexane, THF, 3 deg C, 1 h

5: NaBH₄, AcOH / 15 - 20 °C

With manganese(IV) oxide; sodium tetrahydroborate; sodium methylate; lithium dicyclohexylamide; acetic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00075a020