4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

Base Information

Chemical Name:4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide
CAS No.:1610610-44-0
Molecular Formula:C₂₃H₁₅F₃N₄O
Molecular Weight:420.394
Hs Code.:

Synonyms:4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

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Chemical Property of 4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

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Technology Process of 4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

There total 7 articles about 4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610612-16-2
N-methyl-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridin-5-amine

: 6068-72-0
4-cyanobenzoyl chlorIde

: 1610610-44-0
4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1610611-83-0
3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxylic acid

: 1610610-44-0
4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 4 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; sodium hydride; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: |Curtius Rearrangement;

Reference yield:

: 2459-09-8
4-pyridinecarboxylic acid, methyl ester

: 1610610-44-0
4-cyano-N-methyl-N-(3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: O-(2,4-dinitrophenyl)hydroxylamine / N,N-dimethyl-formamide / 40 °C

1.2: 100 °C

2.1: water; sodium hydroxide / methanol; 1,4-dioxane / 3 h / 20 °C

3.1: diphenyl phosphoryl azide / toluene / 12 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; O-(2,4-dinitrophenyl)hydroxylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: |Curtius Rearrangement;