(5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

Base Information

Chemical Name:(5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one
CAS No.:252340-78-6
Molecular Formula:C₁₄H₁₄FN₃O₃
Molecular Weight:291.282
Hs Code.:

Synonyms:(5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

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Chemical Property of (5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

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Technology Process of (5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

There total 5 articles about (5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 822-36-6
4-methyl-1H-imidazole

: 369-34-6
3,4-difluoronitrobenzene

: 501-53-1,94274-21-2
benzyl chloroformate

: 60456-26-0
(R)-glycidyl butyrate

: 252340-78-6
(5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

Guidance literature:: 4-methyl-1H-imidazole; 3,4-difluoronitrobenzene; With triethylamine; In ethanol; for 72h; Reflux;

In N,N-dimethyl-formamide; acetone; for 5h; Reflux;

benzyl chloroformate; (R)-glycidyl butyrate; Further stages;

Reference yield:

: 252340-74-2
5-Benzyloxycarbonylamino-2-(4-methyl-imidazol-1-yl)fluorobenzene

: 60456-26-0
(R)-glycidyl butyrate

: 252340-78-6
(5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

Guidance literature:: 5-Benzyloxycarbonylamino-2-(4-methyl-imidazol-1-yl)fluorobenzene; With n-butyllithium; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 2-Methylpentane; at -70 ℃; for 1h;

(R)-glycidyl butyrate; In tetrahydrofuran; 2-Methylpentane; at -70 - 20 ℃; for 16.25h;

Reference yield:

: 252337-29-4
3-fluoro-4-(4-methyl-imidazol-1-yl)nitrobenzene

: 252340-78-6
(5R)-3-[3'-fluoro-4'-(4''-methyl-1''H-imidazol-1-yl)phenyl]-5-(hydroxymethyl)-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 48 h / 0 - 20 °C

2.1: pyridine / dichloromethane / 16.5 h / -5 - 20 °C

3.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / -70 °C

3.2: 1 h / 70 °C

3.3: 16.25 h / 20 °C

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; ammonium formate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;