2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Base Information

Chemical Name:2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide
CAS No.:1346447-75-3
Molecular Formula:C₂₂H₂₁ClN₆O₃
Molecular Weight:452.9
Hs Code.:

Synonyms:2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Chemical Property of 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

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Technology Process of 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

There total 5 articles about 2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.5%

: 1346447-74-2
2-(2-(5-amino-2-methoxyphenylamino)-5-chloropyrimidin-4-ylamino)-N-methylbenzamide

: 814-68-6,25189-84-8
acryloyl chloride

: 1346447-75-3
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 761440-08-8
2-[(2,5-dichloropyrimidin-4-yl)amino]-N-methyl-benzamide

: 1346447-75-3
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / isopropyl alcohol / 6 h / 80 °C

2: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

With hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In methanol; dichloromethane; ethyl acetate; isopropyl alcohol;

Reference yield:

: 118-48-9
isatoic anhydride

: 1346447-75-3
2-((2-((5-acrylamido-2-methoxyphenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 0.33 h

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

3: toluene-4-sulfonic acid / isopropyl alcohol / 6 h / 80 °C

4: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;