{trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

Base Information

Chemical Name:{trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid
CAS No.:1450727-64-6
Molecular Formula:C₂₁H₂₄N₄O₄
Molecular Weight:396.446
Hs Code.:

Synonyms:{trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

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Chemical Property of {trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

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Technology Process of {trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

There total 3 articles about {trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450727-79-3
C₃₀H₃₆N₄O₆

: 1450727-64-6
{trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

Guidance literature:: C₃₀H₃₆N₄O₆; With trifluoroacetic acid; In dichloromethane; for 1h;

With dmap; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

With lithium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 1h;
DOI:10.1016/j.bmc.2013.06.045

Reference yield:

: 14160-93-1
4-amino-6-chloro-pyrimidine-5-carbaldehyde

: 1450727-64-6
{trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

1.2: 17 h

2.1: 1,2-dichloro-ethane / 28 h / 60 °C

2.2: 17 h

3.1: trifluoroacetic acid / dichloromethane / 1 h

3.2: 24 h / 60 °C

3.3: 1 h / 50 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; mineral oil;
DOI:10.1016/j.bmc.2013.06.045

Reference yield:

: 1450727-78-2
C₁₅H₁₅N₃O₅

: 1450727-64-6
{trans-4-[4-(4-amino-7-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 28 h / 60 °C

1.2: 17 h

2.1: trifluoroacetic acid / dichloromethane / 1 h

2.2: 24 h / 60 °C

2.3: 1 h / 50 °C

With trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2013.06.045