6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

Base Information

Chemical Name:6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol
CAS No.:494834-77-4
Molecular Formula:C₂₆H₃₆O₄Si
Molecular Weight:440.655
Hs Code.:

6-[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2<i>H</i>-pyran-2-ol

Synonyms:6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

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Chemical Property of 6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

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Technology Process of 6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

There total 10 articles about 6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119879-74-2
(R)-1-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-propan-2-ol

: 494834-77-4
6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 22 °C

2.1: H₂ / Pd(OH)2 / ethyl acetate / 22 °C

3.1: COCl₂; DMSO; Et₃N / CH₂Cl₂ / -78 - 22 °C

4.1: TiCl₄ / CH₂Cl₂ / -78 °C

4.2: 79 percent / TFA / CH₂Cl₂ / 20 °C

5.1: NaBH₄; CeCl₃*7H₂O / ethanol / 0 °C

6.1: aq. camphorsulfonic acid / tetrahydrofuran / Heating

With sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; hydrogen; titanium tetrachloride; sodium hydride; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 3.1: Swern oxidation / 5.1: Luche reduction / 6.1: Ferrier rearrangement;
DOI:10.1021/ja048779q

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 494834-77-4
6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: imidazole / dimethylformamide / 22 °C

2.1: NaH / tetrahydrofuran / 22 °C

3.1: H₂ / Pd(OH)2 / ethyl acetate / 22 °C

4.1: COCl₂; DMSO; Et₃N / CH₂Cl₂ / -78 - 22 °C

5.1: TiCl₄ / CH₂Cl₂ / -78 °C

5.2: 79 percent / TFA / CH₂Cl₂ / 20 °C

6.1: NaBH₄; CeCl₃*7H₂O / ethanol / 0 °C

7.1: aq. camphorsulfonic acid / tetrahydrofuran / Heating

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; hydrogen; titanium tetrachloride; sodium hydride; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 4.1: Swern oxidation / 6.1: Luche reduction / 7.1: Ferrier rearrangement;
DOI:10.1021/ja048779q

Reference yield:

: (3-benzyloxy-2-methoxy-propoxy)-tert-butyl-diphenyl-silane

: 494834-77-4
6-[2-(tert-butyl-diphenyl-silanyloxy)-1-methoxy-ethyl]-3,5-dimethyl-5,6-dihydro-2H-pyran-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / Pd(OH)2 / ethyl acetate / 22 °C

2.1: COCl₂; DMSO; Et₃N / CH₂Cl₂ / -78 - 22 °C

3.1: TiCl₄ / CH₂Cl₂ / -78 °C

3.2: 79 percent / TFA / CH₂Cl₂ / 20 °C

4.1: NaBH₄; CeCl₃*7H₂O / ethanol / 0 °C

5.1: aq. camphorsulfonic acid / tetrahydrofuran / Heating

With sodium tetrahydroborate; cerium(III) chloride; camphor-10-sulfonic acid; hydrogen; titanium tetrachloride; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 2.1: Swern oxidation / 4.1: Luche reduction / 5.1: Ferrier rearrangement;
DOI:10.1021/ja048779q