C₂₂H₃₂N₂O₅SSi

Base Information

• Chemical Name: C₂₂H₃₂N₂O₅SSi
• CAS No.: 1397775-99-3
• Molecular Formula: C₂₂H₃₂N₂O₅SSi
• Molecular Weight: 464.658
• Mol file: 1397775-99-3.mol

Synonyms:C₂₂H₃₂N₂O₅SSi

Chemical Property of C₂₂H₃₂N₂O₅SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₃₂N₂O₅SSi

There total 4 articles about C₂₂H₃₂N₂O₅SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C28H46N2O5SSi2 (1397775-96-0) → C22H32N2O5SSi (1397775-99-3)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201209454

Reference yield:

3',5'-O-di(tert-butyldimethylsilyl)thymidine (40733-26-4) → C22H32N2O5SSi (1397775-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Inert atmosphere; Reflux

2: triethylamine / N,N-dimethyl-formamide / 24 h / 70 °C / Inert atmosphere

3: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

With N-Bromosuccinimide; water; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201209454

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C22H32N2O5SSi (1397775-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Inert atmosphere; Reflux

3: triethylamine / N,N-dimethyl-formamide / 24 h / 70 °C / Inert atmosphere

4: water; trifluoroacetic acid / dichloromethane / 4 h / 0 °C / Inert atmosphere

With 1H-imidazole; N-Bromosuccinimide; water; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201209454

upstream raw materials:

C₂₈H₄₆N₂O₅SSi₂

thymidine

3',5'-O-di(tert-butyldimethylsilyl)thymidine

3′,5′-bis-O-(tert-butyldimethylsilyl)-5-bromomethyl-2'-deoxyuridine

Downstream raw materials:

C₂₆H₃₁N₄O₁₂PS

5-(phenylthiomethyl)-2'-deoxyuridine

C₂₆H₃₁N₄O₁₃PS

thymidylyl (3',5')thymidine