Technology Process of 5-benzyloxy-1-bromo-4-iodo-1,1,2,2-tetrafluoropentane
There total 1 articles about 5-benzyloxy-1-bromo-4-iodo-1,1,2,2-tetrafluoropentane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
benzyl allyl ether;
In
water; acetonitrile;
for 0.25h;
Sonication;
Inert atmosphere;
1-bromo-2-iodo-1,1,2,2-tetrafluoroethane;
With
sodium dithionite; sodium hydrogencarbonate;
In
water; acetonitrile;
at 0 - 6 ℃;
for 21h;
Inert atmosphere;
DOI:10.1021/acs.joc.6b00302
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at -55 - -50 ℃;
for 3h;
DOI:10.1021/acs.joc.6b00302
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / -55 - -50 °C
2.1: (DHQ)2AQN; potassium hexacyanoferrate(III); potassium carbonate; potassium osmate; methanesulfonamide / water; tert-butyl alcohol / 216 h / 0 - 6 °C
3.1: triethylamine; thionyl chloride / dichloromethane / 0.57 h / 0 °C
3.2: 16 h / 0 - 20 °C
4.1: ammonium formate / N,N-dimethyl-formamide / 4 h / 80 °C
4.2: 0.5 h / 20 °C
With
potassium osmate; thionyl chloride; methanesulfonamide; (DHQ)2AQN; ammonium formate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hexacyanoferrate(III);
In
dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/acs.joc.6b00302