(E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

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Chemical Name:(E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one
CAS No.:1446427-44-6
Molecular Formula:C₂₇H₂₇N₃OS
Molecular Weight:441.597
Hs Code.:

Synonyms:(E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

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Chemical Property of (E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

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Technology Process of (E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

There total 3 articles about (E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: C₂₀H₂₀BrN₃O

: 168618-42-6
(2-methylsulfanylphenyl)boronic acid

: 1446427-44-6
(E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;
DOI:10.1055/s-0032-1318391

Reference yield:

: 56759-32-1
1-(4-amino-3-bromophenyl)-ethanone

: 1446427-44-6
(E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / acetonitrile; water / 0.25 h / -10 - 20 °C

1.2: 0.5 h

1.3: 0.5 h / -10 - 20 °C

2.1: barium hydroxide octahydrate / ethanol / 20 °C

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; caesium carbonate; In 1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1055/s-0032-1318391

Reference yield:

: 1361185-97-8
C₁₂H₁₄BrN₃O

: 1446427-44-6
(E)-1-(2'-(methylthio)-6-((E)-pyrrolidin-1-yldiazenyl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: barium hydroxide octahydrate / ethanol / 20 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; caesium carbonate; In 1,4-dioxane; ethanol; water;
DOI:10.1055/s-0032-1318391