[(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

Base Information

Chemical Name:[(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol
CAS No.:135682-55-2
Molecular Formula:C₂₅H₄₂O₃Si
Molecular Weight:418.692
Hs Code.:

Synonyms:[(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

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Chemical Property of [(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

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Technology Process of [(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

There total 9 articles about [(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 133027-57-3,133577-66-9,133644-93-6,135682-54-1,135682-66-5
[1S-(1α,2α,3α,4α)]-α-[2-[3-[[Dimethyl-(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]-7-oxabicyclo[2.2.1]heptane-2,3-dimethanol

: 135682-55-2
[(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

Guidance literature:: With hydrogen; acetic acid; palladium dihydroxide; for 5h; under 760 Torr;
DOI:10.1021/jm00113a030

Reference yield:

: 135682-54-1
<1S-(1α,2α,3α,(S^*),4α)>-α-<2-<3-<oxy>propyl>phenyl>-7-oxabicyclo<2.2.1>heptane-2,3-dimethanol

: 135682-55-2
[(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

Guidance literature:: With hydrogen; palladium hydroxide - carbon; In acetic acid; at 25 ℃; for 24h; under 760 Torr;
DOI:10.1021/jm00062a013

Reference yield:

: 404575-34-4
7-oxabicyclo<2.2.1>heptane tetrahydrofuranol

: 135682-55-2
[(1R,2R,3R,4S)-3-(2-{3-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) EtMgBr / 1.) THF, 0 deg C, 1 h, 2.) THF, 25 deg C, 6 days

2: H₂ / 20percent Pd(OH)2-C / acetic acid / 24 h / 25 °C / 760 Torr

With ethylmagnesium bromide; hydrogen; palladium hydroxide - carbon; In acetic acid;
DOI:10.1021/jm00062a013