3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

Base Information

Chemical Name:3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide
CAS No.:1310805-87-8
Molecular Formula:C₂₅H₂₇N₃O₄S
Molecular Weight:465.573
Hs Code.:

Synonyms:3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

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Chemical Property of 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

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Technology Process of 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

There total 3 articles about 3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96-50-4
2-thiazolylamine

: 1310807-77-2
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxybenzoic acid

: 1310805-87-8
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1310807-75-0
methyl 3-{4-[(cyclopropylmethyl)amino]phenoxy}-5-isopropoxybenzoate

: 1310805-87-8
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 1 h / 20 °C

2: sodium hydroxide; water / methanol / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 20 °C

With pyridine; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1119778-87-8
methyl 3-(4-aminophenoxy)-5-isopropoxybenzoate

: 1310805-87-8
3-{4-[acetyl(cyclopropylmethyl)amino]phenoxy}-5-isopropoxy-N-1,3-thiazol-2-ylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 2 h / 20 °C

2: pyridine / dichloromethane / 1 h / 20 °C

3: sodium hydroxide; water / methanol / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 20 °C

With pyridine; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;