(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

Base Information

Chemical Name:(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate
CAS No.:1193336-52-5
Molecular Formula:C₂₉H₃₂F₇N₃O₃
Molecular Weight:603.58
Hs Code.:

(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

Synonyms:(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

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Chemical Property of (2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

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Technology Process of (2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

There total 9 articles about (2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 1193336-51-4
methyl (2Z,2E)-4-[(2R,4S)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-({[(phenylmethyl)oxy]carbonyl}amino)-4-piperidinyl]-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-butenoate

: 1193336-53-6
(2S,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

: 1193336-52-5
(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

Guidance literature:: With hydrogen; cesium fluoride; palladium 10% on activated carbon; In methanol; for 1h; under 760.051 Torr;

Reference yield:

: 1193336-39-8
1,1-dimethylethyl (2R,4S)-4-amino-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-1-piperidinecarboxylate

: 1193336-52-5
(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

2.2: pH 8

3.1: triethylamine / ethyl acetate / 0 °C

3.2: 0 °C / Reflux

4.1: ozone / dichloromethane / -78 °C / Inert atmosphere

4.2: -78 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1 h / 0 °C

5.2: 0 - 25 °C

5.3: 0 °C

6.1: hydrogen; cesium fluoride / palladium 10% on activated carbon / methanol / 1 h / 760.05 Torr

With hydrogen; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1193336-50-3
phenylmethyl [(2R,4S)-1-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

: 1193336-52-5
(2R,5S,7R)-8-{[{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-7-(4-fluoro-2-methylphenyl)-1,8-diazaspiro[4.5]decane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1 h / 0 °C

1.2: 0 - 25 °C

1.3: 0 °C

2.1: hydrogen; cesium fluoride / palladium 10% on activated carbon / methanol / 1 h / 760.05 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; cesium fluoride; lithium chloride; palladium 10% on activated carbon; In methanol; acetonitrile;