2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene

Base Information

• Chemical Name: 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene
• CAS No.: 1424035-51-7
• Molecular Formula: C₂₄H₂₀O
• Molecular Weight: 324.422
• Mol file: 1424035-51-7.mol

Synonyms:2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene

Chemical Property of 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene

There total 20 articles about 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-bromo-4-methoxy-benzene (104-92-7) + 2-((S)-(2-methoxyethoxy)(phenyl)methyl)naphthalene → 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene (1424035-51-7)

Guidance literature:

1-bromo-4-methoxy-benzene; With iodine; magnesium; In diethyl ether; at 20 ℃; for 2h; Inert atmosphere; Reflux;

2-((S)-(2-methoxyethoxy)(phenyl)methyl)naphthalene; With bis(acetylacetonate)nickel(II); 1,8-bis(diphenylphosphanyl)octane; In diethyl ether; toluene; at 20 ℃; for 48h; optical yield given as %ee; stereospecific reaction; Inert atmosphere;

DOI:10.1002/anie.201202527

Reference yield: 83.0%

C24H18O2 (1426442-12-7) + 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane (213596-33-9) → 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene (1424035-51-7)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; potassium tert-butylate; N,N'-dimesityl-4,5-dihydro-1H-imidazolium tetrafluoroborate; In tetrahydrofuran; toluene; butan-1-ol; at 20 ℃; for 24h; enantiospecific reaction; Inert atmosphere;

DOI:10.1021/ja311783k

Reference yield: 82.0%

C22H21NO2 (1426442-13-8) + 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane (213596-33-9) → 2-((S)-(4-methoxyphenyl)(phenyl)methyl)naphthalene (1424035-51-7)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; potassium tert-butylate; N,N'-dimesityl-4,5-dihydro-1H-imidazolium tetrafluoroborate; In tetrahydrofuran; toluene; butan-1-ol; at 20 ℃; for 24h; enantiospecific reaction; Inert atmosphere;

DOI:10.1021/ja311783k

upstream raw materials:

(S)-naphthalen-2-yl(phenyl)methanol

β-naphthaldehyde

phenylboronic acid

1-bromo-4-methoxy-benzene