6'-HYDROXYMETHYL SIMVASTATIN

Base Information

Chemical Name:6'-HYDROXYMETHYL SIMVASTATIN
CAS No.:128241-03-2
Molecular Formula:C₂₅H₃₈O₆
Molecular Weight:434.573
Hs Code.:
Mol file:128241-03-2.mol

Synonyms:[1S[1a,3a,7a,8b(2S*,4S*),8ab]]1,2,3,7,8,8ahexahydro3(hydroxymethyl)7methyl8[2(tetrahydro4hydroxy6oxo2Hpyran2yl)ethyl]1naphthalenylester2,2dimethylbutanoicAcid;2,2DimethylbutanoicAcid[1S[1a,3a,7a,8(2S*,4S*),8a]]1,2,3,7,8,8ahexahydro3(hydroxymethyl)7methyl8[2(tetrahydro4hydroxy6oxo2Hpyran2yl)ethyl]1naphthalenylEster

Suppliers and Price of 6'-HYDROXYMETHYL SIMVASTATIN

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6'-HYDROXYMETHYL SIMVASTATIN 95.00%
25MG
$ 2243.59

American Custom Chemicals Corporation
6'-HYDROXYMETHYL SIMVASTATIN 95.00%
2.5MG
$ 952.88

Total 4 raw suppliers

Chemical Property of 6'-HYDROXYMETHYL SIMVASTATIN

Chemical Property:

Boiling Point:608.5oC at 760 mmHg
Flash Point:200.9oC
PSA：93.06000
Density:1.16g/cm3
LogP:3.55800

Purity/Quality:

95% ^*data from raw suppliers

6'-HYDROXYMETHYL SIMVASTATIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A metabolite of Simvastatin

Technology Process of 6'-HYDROXYMETHYL SIMVASTATIN

There total 10 articles about 6'-HYDROXYMETHYL SIMVASTATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 125175-64-6
2,2-Dimethyl-butyric acid (1S,4S,5S,6S,7S,9R)-5-{2-[(2R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-4-methyl-11-oxa-tricyclo[7.2.1.0^1,6]dodec-2-en-7-yl ester

: 139408-04-1
(4R,6R)-4-Hydroxy-6-[2-((R)-6-hydroxymethyl-2-methyl-5,6,7,8-tetrahydro-naphthalen-1-yl)-ethyl]-tetrahydro-pyran-2-one

: 114883-29-3,128241-03-2
6’-hydroxymethyl simvistatin

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 60 ℃;
DOI:10.1021/jo00033a012

Reference yield:

: 114801-27-3,128241-03-2
6(R)-[2-[6(S)-hydroxymethyl-8(S)-(2,2-dimethylbutyryloxy)-2(S)-methyl-1,2,6,7,8,8a(R)-hexahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:

Reference yield:

: 123049-81-0,79902-63-9
simvastatin

: 114883-29-3,128241-03-2
6’-hydroxymethyl simvistatin

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide

2: CH₂Cl₂ / -78 °C

3: 30percent H₂O₂ / tetrahydrofuran / 0 deg C to r.t.

4: 92 percent / tri-n-butyltin hydride, AIBN / benzene / Heating

5: I₂, HgO, pyridine / CCl₄ / Ambient temperature

6: (n-Bu₃Sn)2, pyridine / benzene / Heating; Irradiation

7: 58 percent / 48percent HF / acetonitrile / 60 °C

With pyridine; 1H-imidazole; 2,2'-azobis(isobutyronitrile); hydrogen fluoride; dihydrogen peroxide; iodine; tri-n-butyl-tin hydride; bis(tri-n-butyltin); mercury(II) oxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00033a012