Technology Process of 1,3,6',3''-tetraazido-4'',6''-O-benzylidene-3',4',2''-tri-O-benzyl-5,2'-di-O-allylkanamycin A
There total 6 articles about 1,3,6',3''-tetraazido-4'',6''-O-benzylidene-3',4',2''-tri-O-benzyl-5,2'-di-O-allylkanamycin A which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,3,6',3''-tetraazido-4'',6''-O-benzylidene-3',4',2''-tri-O-benzylkanamycin A;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.0833333h;
allyl bromide;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 3h;
DOI:10.1021/jo302247x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate; methanol / 4 h / 20 °C / pH 11
2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 12 h / 68 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C
3.2: 6 h / 0 - 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran; methanol / 3 h / 50 °C
4.2: anion resin
5.1: toluene-4-sulfonic acid; water / acetonitrile / 3 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C
6.2: 3 h / 0 - 20 °C
With
hydrogenchloride; methanol; water; sodium methylate; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo302247x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium azide; trifluoromethylsulfonic anhydride; copper(II) sulfate; triethylamine / acetonitrile; water / 0 - 20 °C
2.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 12 h / 68 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C
3.2: 6 h / 0 - 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran; methanol / 3 h / 50 °C
4.2: anion resin
5.1: toluene-4-sulfonic acid; water / acetonitrile / 3 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C
6.2: 3 h / 0 - 20 °C
With
hydrogenchloride; sodium azide; trifluoromethylsulfonic anhydride; water; sodium hydride; toluene-4-sulfonic acid; copper(II) sulfate; triethylamine;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo302247x
