(2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

Base Information

Chemical Name:(2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol
CAS No.:259856-84-3
Molecular Formula:C₁₉H₃₂O₂S₂Si
Molecular Weight:384.679
Hs Code.:

Synonyms:(2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

Chemical Property:

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Technology Process of (2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

There total 1 articles about (2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 5425-44-5
2-Phenyl-[1,3]dithiane

: 78906-15-7,114413-26-2,124150-87-4,123237-62-7
tert-butyldimethylsilyl (S)-glycidyl ether

: 259856-84-3
(2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

Guidance literature:: 2-Phenyl-[1,3]dithiane; With n-butyllithium; In tetrahydrofuran; hexane; at -25 ℃; for 2h;

tert-butyldimethylsilyl (S)-glycidyl ether; In tetrahydrofuran; for 5h;
DOI:10.1016/S0957-4166(99)00458-9

Reference yield:

: 259856-84-3
(2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

: Methanesulfonic acid (R)-1-hydroxymethyl-2-(2-phenyl-[1,3]dithian-2-yl)-ethyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/S0957-4166(99)00458-9

Reference yield:

: 259856-84-3
(2R)-1-(tert-butyldimethylsilyloxy)-4-(1,3-dithian-2-yl)-4-phenyl-2-butanol

: 1026470-49-4
Trifluoro-acetic acid (2S,4R)-2-phenyl-1-(2,2,2-trifluoro-acetyl)-piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: aq.nBu₄NF / tetrahydrofuran / 1 h / 0 °C

2: K₂CO₃ / tetrahydrofuran / 12 h / 20 °C

3: 80 percent / LiClO₄ / acetonitrile / 70 °C

4: 80 percent / Hg(ClO₄)2; CaCO₃ / tetrahydrofuran; H₂O / 2 h / 20 °C

5: 33 percent / H₂ / PtO₂ / ethanol / 12 h / 20 °C

6: Et₃N; dimethylaminopyridine / CH₂Cl₂ / 12 h / 23 °C

With dmap; mercury(II) perchlorate; tetrabutyl ammonium fluoride; hydrogen; lithium perchlorate; potassium carbonate; triethylamine; calcium carbonate; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 1: selective deprotection / 2: Cyclization / 3: Alkylation / 4: Hydrolysis / 5: Hydrogenation / 6: Acetylation;
DOI:10.1016/S0957-4166(99)00458-9