(+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt

Base Information

Chemical Name:(+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt
CAS No.:1280716-67-7
Molecular Formula:C₈H₁₁N*C₁₀H₇F₃N₂O₂
Molecular Weight:365.355
Hs Code.:

Synonyms:(+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt

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Technology Process of (+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt

There total 2 articles about (+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1280716-66-6
(+)-(S)-5-phenyl-5-(trifluoromethyl)hydantoin

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1280716-67-7
(+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt

Guidance literature:: In ethanol; for 0.0833333h;
DOI:10.1016/j.tetasy.2010.11.029

Reference yield:

: 434-45-7
2,2,2-Trifluoroacetophenone

: 1280716-67-7
(+)-(R)-α-methylbenzylamine (S)-(+)-5-phenyl-5-(trifluoromethyl)hydantoin salt

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; water / 38 h / 110 - 120 °C / Autoclave

2: ethanol / 48 h / -15 - 30 °C / Resolution of racemate; Auto-seeded programmed polythermic preferential crystallization

3: ethanol / 0.08 h

In ethanol; water; 1: Bucherer-Bergs reaction;
DOI:10.1016/j.tetasy.2010.11.029