4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

Base Information

Chemical Name:4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester
CAS No.:130851-55-7
Molecular Formula:C₂₅H₃₅IO₁₁
Molecular Weight:638.451
Hs Code.:

4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

Synonyms:4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

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Chemical Property of 4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

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Technology Process of 4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

There total 4 articles about 4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 115592-74-0,115650-45-8,127761-05-1
4-Hydroxy-5-iod-2,3-dimethoxy-6-methyl-benzoesaeuremethylester

: 130851-54-6
2,2-Dimethyl-propionic acid (2S,3R,4R,5S,6S)-5-acetoxy-2-bromo-4-methoxy-6-methyl-tetrahydro-pyran-3-yl ester

: 130851-55-7
4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

Guidance literature:: With silver carbonate; In toluene; at 50 ℃; for 4h;
DOI:10.1016/S0040-4039(00)97556-7

Reference yield:

: 130851-52-4
methyl 4-O-benzyl-3-O-methyl-2-O-pivaloyl-α-L-rhamnopyranoside

: 130851-55-7
4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / AcOH, H₂SO₄ / 16 h / 25 °C

2: 94 percent / HBr, AcOH / CH₂Cl₂ / 18 h / 0 to 25 deg C

3: 41 percent / Ag₂CO₃ on Celite / toluene / 4 h / 50 °C

With sulfuric acid; hydrogen bromide; acetic acid; silver carbonate; In dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)97556-7

Reference yield:

: 130851-53-5
acetyl 4-O-acetyl-3-O-methyl-2-O-pivaloyl-α-L-rhamnopyranoside

: 130851-55-7
4-[(2S,3R,4R,5S,6S)-5-Acetoxy-3-(2,2-dimethyl-propionyloxy)-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy]-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / HBr, AcOH / CH₂Cl₂ / 18 h / 0 to 25 deg C

2: 41 percent / Ag₂CO₃ on Celite / toluene / 4 h / 50 °C

With hydrogen bromide; acetic acid; silver carbonate; In dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)97556-7