1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane

Base Information

• Chemical Name: 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane
• CAS No.: 151915-09-2
• Molecular Formula: C₄₄H₅₆N₄O₆S₂
• Molecular Weight: 801.084
• Mol file: 151915-09-2.mol

Synonyms:1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane

Chemical Property of 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane

There total 6 articles about 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-ethyl-N-(3-iodopropyl)-(2-mesitylene)sulfonamide (151915-08-1) + 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane (151915-06-9) → 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane (151915-09-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

DOI:10.1021/jm00072a020

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) → 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane (151915-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / 10percent aq. NaOH / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, THF, RT, 4 h

3: 96 percent / NaH / dimethylformamide / 0.5 h / 0 °C

With sodium hydroxide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00072a020

Reference yield:

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) → 1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane (151915-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Na₂CO₃, LiI / butan-1-ol / 24 h / 80 °C

2: 96 percent / NaH / dimethylformamide / 0.5 h / 0 °C

With sodium hydride; sodium carbonate; lithium iodide; In N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1021/jm00072a020

upstream raw materials:

N-ethyl-N-(3-iodopropyl)-(2-mesitylene)sulfonamide

1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane

2-mesitylenesulphonyl chloride

2-(3-bromopropyl)isoindole-1,3-dione

Downstream raw materials:

1-{[(cyclopropyl)methyl]amino}-11-(ethylamino)-4,8-diazaundecane tetrahydrobromide

1-(propargylamino)-11-(ethylamino)-4,8-diazaundecane tetrahydrobromide

1-amino-4,8-bis-11-amino-4,8-diazaundecane

1-phthalimido-4,8-bis-11-amino-4,8-diazaundecane