N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

Base Information

Chemical Name:N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide
CAS No.:1438638-86-8
Molecular Formula:C₂₅H₂₆N₆O₂S₂
Molecular Weight:506.652
Hs Code.:

Synonyms:N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

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Chemical Property of N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

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Technology Process of N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

There total 3 articles about N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1334921-38-8
N-(4-(4-iodo-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

: 1439936-58-9
5-(2-(dimethylamino)ethoxy)pyrazine-2-thiol

: 1438638-86-8
N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

Guidance literature:: With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield: 15.0%

: 1439936-58-9
5-(2-(dimethylamino)ethoxy)pyrazine-2-thiol

: N-[5-(4-iodo-2,6-dimethylphenyl)thiazol-2-yl]isonicotinamide

: 1438638-86-8
N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

Guidance literature:: With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112118

Reference yield:

: 1049024-78-3
2-((5-bromopyrazin-2-yl)oxy)-N,N-dimethylethanamine

: 1438638-86-8
N-{4-[4-({5-[2-(dimethylamino)ethoxy]pyrazin-2-yl}thio)-2,6-dimethylphenyl]thiazol-2-yl}isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 100 °C

With copper(l) iodide; sodium monohydrogen sulfide x-hydrate; potassium carbonate; In N,N-dimethyl-formamide;