(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

Base Information

Chemical Name:(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol
CAS No.:929008-36-6
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-<i>d</i>]isoxazol-8-yl)-methanol

Synonyms:(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

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Chemical Property of (2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

Chemical Property:

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Technology Process of (2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

There total 7 articles about (2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 929008-34-4
(3aR,8R,8aR)-2-benzyl-8-t-butyldiphenylsiloxymethyl-6,6-dimethyl-5,7-dioxa-isoxazolidino[4,5]cycloheptane

: 929008-36-6
(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1080/07328300601039336

Reference yield:

: 2-benzyl-4-oxo-hexahydro-furo[3,4-d]isoxazole-6-carbaldehyde

: 929008-36-6
(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 0.16 g / NaBH(OAc)3 / CH₂Cl₂

2: 73 percent / DMAP / CH₂Cl₂

3: LiAlH₄ / tetrahydrofuran / 0.5 h

4: 0.38 g / p-TsOH / 2 h / Heating

5: 90 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1080/07328300601039336

Reference yield:

: 929008-31-1
(3aR,6R,6aR)-2-benzyl-6-hydroxymethyl-4-oxo-isoxazolidino[4,5-c]tetrahydrofuran

: 929008-36-6
(2-benzyl-6,6-dimethyl-hexahydro-[1,3]dioxepino[5,6-d]isoxazol-8-yl)-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / DMAP / CH₂Cl₂

2: LiAlH₄ / tetrahydrofuran / 0.5 h

3: 0.38 g / p-TsOH / 2 h / Heating

4: 90 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1080/07328300601039336