(5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE

Base Information

Chemical Name:(5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE
CAS No.:121269-46-3
Molecular Formula:C18H17 N O4
Molecular Weight:311.33
Hs Code.:
Mol file:121269-46-3.mol

Synonyms:4-Morpholinecarboxylicacid, 2-oxo-5-phenyl-, phenylmethyl ester, (R)-

Suppliers and Price of (5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE 95.00%
5MG
$ 500.95

AHH
(5R)-3,4,5,6-Tetrahydro-5-phenyl-N-(benzyloxycarbonyl)-4(H)-1,4-oxazin-2-one 98%
10g
$ 580.00

Total 6 raw suppliers

Chemical Property of (5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE

Chemical Property:

PSA：55.84000
LogP:2.86120

Purity/Quality:

98%min ^*data from raw suppliers

(5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE

There total 5 articles about (5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-N-(BENZYLOXYCARBONYL)-4(H)-1,4-OXAZIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 121269-45-2,134872-85-8
(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one

: 501-53-1,94274-21-2
benzyl chloroformate

: 121269-46-3
(5R)-2,3,5,6-tetrahydro-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jo00277a032

Reference yield:

: 201018-12-4
[Benzyloxycarbonyl-((R)-2-hydroxy-1-phenyl-ethyl)-amino]-acetic acid ethyl ester

: 121269-46-3
(5R)-2,3,5,6-tetrahydro-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazin-2-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; Yield given;
DOI:10.1016/0957-4166(96)00324-2

Reference yield:

: ((R)-2-Hydroxy-1-phenyl-ethylamino)-acetic acid ethyl ester

: 121269-46-3
(5R)-2,3,5,6-tetrahydro-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaHCO₃ / CH₂Cl₂ / 1 h

2: 2.47 g / pTSA / toluene

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In dichloromethane; toluene;
DOI:10.1081/SCC-120021497