(1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester
• CAS No.: 121772-21-2
• Molecular Formula: C₁₆H₃₂O₄Si
• Molecular Weight: 316.513
• Mol file: 121772-21-2.mol

Synonyms:(1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester

Chemical Property of (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester

There total 3 articles about (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + methyl (1S,2S,6S)-2-hydroxy-1,6-dimethylcyclohexanecarboxylate (121842-99-7) → (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester (121772-21-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1002/hlca.19880710505

Reference yield:

(2S,4aS,5S,8aS)-2-(tert-butyl)perhydro-4a,5-dimethyl-2H,4H-<1,3>benzodioxin-4-one (121842-98-6) → (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester (121772-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / LiOH / tetrahydrofuran; methanol; H₂O / Ambient temperature

2: 99 percent / diethyl ether / 0 °C

3: 98 percent / (i-Pr)2NEt / CH₂Cl₂ / Ambient temperature

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

DOI:10.1002/hlca.19880710505

Reference yield:

(1S,2S,6S)-2-Hydroxy-1,6-dimethyl-cyclohexanecarboxylic acid (121772-20-1) → (1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarboxylic acid methyl ester (121772-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / diethyl ether / 0 °C

2: 98 percent / (i-Pr)2NEt / CH₂Cl₂ / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

DOI:10.1002/hlca.19880710505

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

methyl (1S,2S,6S)-2-hydroxy-1,6-dimethylcyclohexanecarboxylate

(2S,4aS,5S,8aS)-2-(tert-butyl)perhydro-4a,5-dimethyl-2H,4H-<1,3>benzodioxin-4-one

(1S,2S,6S)-2-Hydroxy-1,6-dimethyl-cyclohexanecarboxylic acid

Downstream raw materials:

(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

(1S,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexanecarbaldehyde

(2R,3S)-2,3-Dimethyl-2-((E)-3-oxo-but-1-enyl)-cyclohexanone

(E)-4-((1R,2S,6S)-2-Hydroxy-1,6-dimethyl-cyclohexyl)-but-3-en-2-one