3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

Base Information

Chemical Name:3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester
CAS No.:864677-91-8
Molecular Formula:C₂₂H₂₈O₄
Molecular Weight:356.462
Hs Code.:

Synonyms:3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

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Chemical Property of 3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

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Technology Process of 3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

There total 5 articles about 3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 864677-87-2
C₁₇H₁₉BrO₂

: 140-88-5,9003-32-1
ethyl acrylate

: 864677-91-8
3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

Guidance literature:: With pyridine; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; ethylene dibromide; nickel dibromide; In N,N-dimethyl-formamide; at 100 ℃; Electrochemical reaction;
DOI:10.1055/s-2005-865364

Reference yield:

: 52221-92-8
3-(2-bromo-phenyl)-propan-1-ol

: 864677-91-8
3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

1.2: 82 percent / TBAI / tetrahydrofuran / 4 h / 50 °C

2.1: 64 percent / TBAB; TBAI; pyridine / 1,2-dbromoethane; NiBr₂*3H₂O / dimethylformamide / 100 °C / Electrochemical reaction

With pyridine; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; ethylene dibromide; nickel dibromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-865364

Reference yield:

: 91047-77-7
ethyl (2E)-3-(2-bromophenyl)prop-2-enoate

: 864677-91-8
3-{2-[3-(4-methoxy-benzyloxy)-propyl]-phenyl}-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiBEt₃H / tetrahydrofuran / 19 h / -78 - 20 °C

1.2: H₂O / tetrahydrofuran / 2 h / Heating

1.3: 91 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 1 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h / 20 °C

2.2: 82 percent / TBAI / tetrahydrofuran / 4 h / 50 °C

3.1: 64 percent / TBAB; TBAI; pyridine / 1,2-dbromoethane; NiBr₂*3H₂O / dimethylformamide / 100 °C / Electrochemical reaction

With pyridine; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium triethylborohydride; ethylene dibromide; nickel dibromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-865364