t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate

Base Information

• Chemical Name: t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate
• CAS No.: 1318243-02-5
• Molecular Formula: C₂₂H₂₅N₅O₃S
• Molecular Weight: 439.538
• Mol file: 1318243-02-5.mol

Synonyms:t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate

Chemical Property of t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate

There total 12 articles about t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl 3-amino-4-methylphenylcarbamate (660838-05-1) + 4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxylic acid (1318242-88-4) → t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate (1318243-02-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate (1318243-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 18 h / 65 °C

2: hydrogen / ethanol / 2 h / 2585.81 Torr

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

(4-methyl-3-nitro-phenyl)-carbamic acid tert-butyl ester (630410-29-6) → t-butyl 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylphenylcarbamate (1318243-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / ethanol / 2 h / 2585.81 Torr

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl dicarbonate

3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine

7-methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one

Downstream raw materials:

N-(5-amino-2-methylphenyl)-4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamide