[4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid

Base Information

• Chemical Name: [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid
• CAS No.: 688744-97-0
• Molecular Formula: C₂₀H₂₉N₅O₈
• Molecular Weight: 467.479

Synonyms:[4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid

Chemical Property of [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid

Chemical Property:

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Technology Process of [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid

There total 3 articles about [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

bromoacetic acid (79-08-3) + 1-(4-nitrophenyl)-1,4,7,10-tetraazacyclododecane (688744-99-2) → [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid (688744-97-0)

Guidance literature:

With sodium hydroxide; In water; at 50 ℃; for 6h; pH=10;

DOI:10.1002/ejic.200300356

Reference yield:

1,4,7,10-tetraazacyclododecan (294-90-6) → [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid (688744-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70.8 percent / acetonitrile; H₂O / 8 h / 60 °C

2: 87.6 percent / NAOH / H₂O / 6 h / 50 °C / pH 10

With sodium hydroxide; In water; acetonitrile;

DOI:10.1002/ejic.200300356

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → [4,7-Bis-carboxymethyl-10-(4-nitro-phenyl)-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid (688744-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70.8 percent / acetonitrile; H₂O / 8 h / 60 °C

2: 87.6 percent / NAOH / H₂O / 6 h / 50 °C / pH 10

With sodium hydroxide; In water; acetonitrile;

DOI:10.1002/ejic.200300356

upstream raw materials:

bromoacetic acid

1-(4-nitrophenyl)-1,4,7,10-tetraazacyclododecane

1,4,7,10-tetraazacyclododecan

4-Fluoronitrobenzene

Downstream raw materials:

[4-(4-Amino-phenyl)-7,10-bis-carboxymethyl-1,4,7,10-tetraaza-cyclododec-1-yl]-acetic acid

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