2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane

Base Information

• Chemical Name: 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane
• CAS No.: 120447-66-7
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 217.311
• Mol file: 120447-66-7.mol

Synonyms:2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane

Chemical Property of 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane

There total 4 articles about 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(E)-2-bromoethenyl]benzene (588-72-7,1340-14-3) → 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane (120447-66-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-butyllithium / 1.) THF, hexane; 2.) -78 deg C, 2 h; room temp., 2 h

2: 95 percent / sodium cyanoborohydride, methyl orange / methanol / pH 3-4

3: Na₂SO₄ / benzene / 10 h / Heating

4: benzene / 10 h / Heating

With n-butyllithium; methyl orange; sodium cyanoborohydride; sodium sulfate; In methanol; benzene;

DOI:10.1021/ja00191a038

Reference yield:

(E)-6-Phenyl-5-hexen-2-one oxime (82194-04-5) → 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane (120447-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / sodium cyanoborohydride, methyl orange / methanol / pH 3-4

2: Na₂SO₄ / benzene / 10 h / Heating

3: benzene / 10 h / Heating

With methyl orange; sodium cyanoborohydride; sodium sulfate; In methanol; benzene;

DOI:10.1021/ja00191a038

Reference yield:

N-<(E)-1-Methyl-5-phenyl-4-pentenyl>hydroxylamine (120474-38-6) → 2-endo,8-exo-Dimethyl-6-exo-phenyl-7-oxa-1-azabicyclo<3.2.1>octane (120447-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂SO₄ / benzene / 10 h / Heating

2: benzene / 10 h / Heating

With sodium sulfate; In benzene;

DOI:10.1021/ja00191a038

upstream raw materials:

[(E)-2-bromoethenyl]benzene

(E)-6-Phenyl-5-hexen-2-one oxime

N-<(E)-1-Methyl-5-phenyl-4-pentenyl>hydroxylamine