3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

Base Information

Chemical Name:3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile
CAS No.:1607429-02-6
Molecular Formula:C₂₂H₂₂N₆O₃
Molecular Weight:418.455
Hs Code.:

Synonyms:3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

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Chemical Property of 3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

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Technology Process of 3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

There total 11 articles about 3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607428-97-6
3-chloro-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

: 34851-41-7
tetrabutyl ammonium methoxide

: 1607429-02-6
3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

Guidance literature:: In methanol; at 50 - 60 ℃;

Reference yield:

: 1222491-29-3
[(2R,5S)-5-hydroxy-2-methylpiperidin-1-yl][2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

: 1607429-02-6
3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere

2: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

3: sodium hydride / dimethyl sulfoxide / 45 °C

4: methanol / 50 - 60 °C

With methanol; sodium hydride; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 1607429-02-6
3-methoxy-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridin-4-carbonitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol / 70 °C / 2585.81 Torr

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / 0.17 h / -78 °C

3.2: 0.25 h / -78 °C

4.1: lithium borohydride; methanol / tetrahydrofuran / -10 - 20 °C

5.1: carbon dioxide / methanol

6.1: palladium 10% on activated carbon; hydrogen / ethanol

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 50 °C

8.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 - 20 °C / Inert atmosphere

9.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

10.1: sodium hydride / dimethyl sulfoxide / 45 °C

11.1: methanol / 50 - 60 °C

With hydrogenchloride; methanol; platinum(IV) oxide; lithium borohydride; 1-hydroxy-7-aza-benzotriazole; oxalyl dichloride; carbon dioxide; palladium 10% on activated carbon; hydrogen; sodium hydride; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 3.1: |Swern Oxidation;