(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

Base Information

Chemical Name:(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane
CAS No.:1309943-84-7
Molecular Formula:C₂₈H₂₈ClN₅O₂
Molecular Weight:502.016
Hs Code.:

Synonyms:(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

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Chemical Property of (1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

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Technology Process of (1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

There total 1 articles about (1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2396-63-6
hepta-1,6-diyne

: 1078503-80-6
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-iodobenzylamino)-9H-purin-9-yl)-2,3-O-isopropylidine-bicyclo[3.1.0]hexane

: 1309943-84-7
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 92.0%

: 1309943-84-7
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

: 1309943-86-9
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; water; at 20 ℃;

Reference yield:

: 1309943-84-7
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(hepta-1,6-diynyl)benzylamino)-9H-purin-9-yl)-2,3-O-isopropylidenebicyclo[3.1.0]hexane

: 1309943-89-2
(1R,2R,3S,4R,5S)-4-(2-chloro-6-(3-(5-(1-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)pent-1-ynyl)benzylamino)-9H-purin-9-yl)bicyclo[3.1.0]hexane-2,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / dichloromethane; water / 20 °C

2: sodium L-ascorbate; copper(II) sulfate / tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / dichloromethane; water; tert-butyl alcohol / 20 °C

With trifluorormethanesulfonic acid; copper(II) sulfate; sodium L-ascorbate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In dichloromethane; water; tert-butyl alcohol;