N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine

Base Information

• Chemical Name: N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine
• CAS No.: 127565-73-5
• Molecular Formula: C₄₀H₄₂N₄O₈S₄
• Molecular Weight: 835.059
• Mol file: 127565-73-5.mol

Synonyms:N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine

Chemical Property of N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine

There total 2 articles about N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) + N,N'-<(ethanodithio)ethano>bis- (23516-74-7) → N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine (127565-73-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 48h;

DOI:10.1016/S0040-4020(01)89522-3

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine (127565-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. NaOH / H₂O; diethyl ether / 1.) 1 h, 0 deg C; 2.) 2 h, r.t.

2: 84 percent / potassium carbonate, tetrabutylammonium iodide / dimethylformamide / 48 h / 80 °C

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; In diethyl ether; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)89522-3

Reference yield: 80.0%

N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-phtalimidopropyl)cystamine (127565-73-5) → N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-aminopropyl)cystamine (127565-74-6)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 10h;

DOI:10.1016/S0040-4020(01)89522-3

upstream raw materials:

2-(3-bromopropyl)isoindole-1,3-dione

N,N'-<(ethanodithio)ethano>bis-

p-toluenesulfonyl chloride

Downstream raw materials:

N,N'-bis-(paratoluenesulfonyl)-N,N'-bis(3-aminopropyl)cystamine

N,N'-bis(3-aminopropyl)cystamine tetrahydrobromide